Evaluation of EU risk assessments existing chemicals (EC Regulation 793/93)

Risk Evaluation of Endocrine-Disrupting Chemicals

We review here our studies on early exposure to low doses of the estrogenic endocrine-disrupting chemical bisphenol A (BPA) on behavior and metabolism in CD-1 mice. Mice were exposed in utero from gestation day (GD) 11 to delivery (prenatal exposure) or via maternal milk from birth to postnatal day 7 (postnatal exposure) to 10 mg/kg body weight/d of BPA or no BPA (controls). Bisphenol A exposur...

The EU hazard concept ” and EU approaches towards chemicals management

Dissemination of the Commission Regulation (EC) No 352/2009/EC on Common Safety Method on Risk Evaluation and Assessment

In order to support the market opening across Europe, the European Commission decided to define a common and harmonised approach for managing the railway safety. To take this forward, the EU Legislators have approved in April 2004 the railway safety directive 2004/49/EC. This directive allocates amongst others the task of defining a Common Safety Method (CSM) on risk evaluation and assessment t...

ECVAM, ECETOC and the EU chemicals policy.

ECVAM's initiatives in validation have received significant support from the European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC), especially through the provision of reference chemical data banks, which contain peer-reviewed, high-quality in vivo data on commercially available chemical substances. Chemicals have been selected from these ECETOC data banks for validation studie...

Regulation of New Chemicals